Science
Mechanism of Action
Ethyl Acetoacetate functions as an inhibitor of bacterial biofilm and an antibacterial agent, targeting specific bacterial strains to mitigate their proliferation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In laboratory settings, Ethyl Acetoacetate demonstrated effectiveness as a bacterial biofilm inhibitor, with IC50 values ranging from 0.31 to 5.6 mg/mL against species such as Cronobacter sakazakii, Serratia marcescens, and Yersinia enterocolitica.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is generally stable but should not be combined with strong acids, bases, oxidizing or reducing agents, or alkali metals. It exhibits an approximate pH of 4.0 in a 110 g/L aqueous solution at 20°C and may react slowly with aldehydes present in fragrance compositions, potentially leading to a loss of odor impact.
Conflicts
- strong acids
- strong bases
- oxidizing agents
- reducing agents
- alkali metals
- aldehydes (in fragrances)
Safety
Safety Profile
While not formally reviewed by the CIR, the European Commission (2002) observed very minimal dermal irritation and no skin sensitizing potential based on long-standing human experience, particularly in cosmetic nail lacquers. It was, however, noted as slightly irritating for the rabbit eye. Studies indicated it is not genotoxic and not anticipated to be phototoxic or photoallergenic. The FDA classifies Ethyl Acetoacetate as Generally Recognized As Safe (GRAS) for use as a flavoring agent or adjuvant in food.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ethyl Acetoacetate presents as a valuable ingredient for its precise antibacterial and anti-biofilm capabilities, suitable for formulations targeting skin purity and microbiome balance.
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References
Sources