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Moumoujus

ETHYL 3-PHENYLGLYCIDATE.

Avoid CAS 121-39-1 / PERFUMING

Ethyl 3-phenylglycidate is an organic compound featuring both epoxide and ester functional groups. While utilized across various industries as a flavoring and fragrance agent, its chemical structure confers high reactivity, making it a potential concern for dermal applications.

Summary

Science

Mechanism of Action

As an epoxide, Ethyl 3-phenylglycidate possesses inherent chemical reactivity. It is prone to polymerization in the presence of catalysts or heat and can react with strong acids, bases, and oxidizing agents. In a dermatological context, this reactivity suggests a propensity for adverse interactions rather than specific skin benefits.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient exhibits stability under neutral pH conditions. However, it is highly sensitive to strong acids and bases, which can induce polymerization. It is also incompatible with strong oxidizing agents.

Conflicts

  • strong acids
  • strong bases
  • oxidizing agents
  • catalysts
  • heat
  • water (in presence of acid/catalysts)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The European Chemicals Agency (ECHA) classifies Ethyl 3-phenylglycidate as a Skin Sensitizer 1B (99.6%), indicating a high potential to cause allergic skin reactions. It is also considered an irritant. While the US FDA deems it Generally Recognized As Safe (GRAS) for food flavoring, its dermal application carries significant risk.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its classification as a Skin Sensitizer 1B (99.6%), high irritancy potential, and inherent chemical reactivity without demonstrated skin benefits, Ethyl 3-phenylglycidate is unequivocally unsuitable for precision skincare formulations.

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