Science
Mechanism of Action
Upon dermal absorption, Ethoxyethanol Acetate is metabolized within the body, primarily in the blood and liver. It rapidly hydrolyzes to 2-ethoxyethanol, which is subsequently converted by alcohol dehydrogenase to 2-ethoxyacetaldehyde, and further by aldehyde dehydrogenase to 2-ethoxyacetic acid (2-EAA). These metabolites, particularly 2-EAA, are the primary agents responsible for its toxic effects. Additionally, it possesses skin defatting properties that can lead to dryness and compromise skin barrier integrity.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ethoxyethanol Acetate is incompatible with strong acids, strong bases, and strong oxidants. There is also a risk of unstable peroxide formation.
Conflicts
- strong acids
- strong bases
- strong oxidants
- nitrates
- plastics (can soften)
- rubber (can attack)
- coatings (can attack)
Safety
Safety Profile
The CIR Expert Panel concluded in 1998 that Ethoxyethanol Acetate is unsafe for cosmetic use. The SCCNFP also deems it a health risk, classifying it as toxic to reproduction (category 2), leading to its prohibition in cosmetic products within the European Union. This chemical is readily absorbed through human skin and is a known reproductive and developmental toxicant (teratogen). Studies indicate potential for kidney damage (including severe tubular degeneration), injury to bone marrow and blood cells (anemia), and testicular damage, alongside possible liver damage. It is also documented as a mild skin irritant and a mild to moderate eye irritant.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its established reproductive and developmental toxicity, classification as unsafe for cosmetic use by expert panels, and prohibition in the European Union, Ethoxyethanol Acetate should be entirely avoided in skincare formulations.
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References
Sources