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Moumoujus

ETHOXY-P-CRESOL.

Avoid CAS 2563-07-7 / PERFUMING

Ethoxy-p-cresol, chemically known as 4-(Ethoxymethyl)phenol, has demonstrated potent antioxidant capabilities in *in vitro* studies. However, its application in skincare is significantly constrained due to substantial safety concerns.

Summary

Fragrance Preservative

Science

Mechanism of Action

While no specific beneficial mechanism for skin has been substantiated through clinical research, *in vitro* investigations indicate that 4-(Ethoxymethyl)phenol may function as a potent antioxidant.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for the stability of Ethoxy-p-cresol in cosmetic formulations has been identified. Similar to p-Cresol, it is expected to exhibit moderate solubility in water and good solubility in organic solvents such as ethanol, ether, and chloroform.

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
0.5%
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel found insufficient data to assess the safety of related p-Cresol and Mixed Cresols in cosmetics, particularly regarding skin whitening and sensitization. A conservative concentration limit of 0.5% has been suggested for other cresol derivatives to prevent chemical leukoderma. Ethoxy-p-cresol is designated as 'Restricted' by EWG Skin Deep and categorized as a 'Human toxicant or allergen - strong evidence' by the International Fragrance Association (IFRA). There is no specific SCCS or FDA regulatory status available for this compound.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its categorization as a human toxicant and allergen with strong evidence by IFRA, and a lack of sufficient safety data, this ingredient is not recommended for use in precision skincare formulations.

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