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Moumoujus

ETHOXY-METHOXYMETHYL-PHENOL.

Questionable CAS 5595-79-9 / PERFUMING

ETHOXY-METHOXYMETHYL-PHENOL is a compound predominantly utilized as a fragrance ingredient in various cosmetic and household products. While it belongs to the phenol chemical class, specific clinical data for its active use in skincare is not available.

Summary

Fragrance Agent

Science

Mechanism of Action

As a phenolic compound, its theoretical mechanism, extrapolated from general phenol properties, could involve protein denaturation and precipitation, which might lead to coagulation necrosis and stimulate deep dermal remodeling, including collagen and elastin production. Some related 4-substituted phenols also suggest potential for inhibiting melanin synthesis and tyrosinase activity. However, its primary documented biological activity is as a fragrance agent, not a skincare active.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Phenolic compounds are generally prone to oxidation in alkaline conditions, therefore maintaining a neutral to slightly acidic pH is crucial for stability in aqueous solutions. The ingredient may also be air sensitive.

Conflicts

  • Alkaline pH (increases oxidation susceptibility)
  • Ingredients that enhance skin penetration (e.g., croton oil, olive oil, cresol, sodium salicylate, camphor, glycerin, soaps), as these may elevate the risk of systemic toxicity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Research Institute for Fragrance Materials (RIFM) has conducted a safety assessment using a closely related compound, indicating an adequate Margin of Exposure (MOE) for repeated dose toxicity at current use levels and no genotoxic potential. However, PubChem lists GHS classifications including 'May cause an allergic skin reaction' (H317). For related compounds, 'Causes skin irritation' (H315) and 'Causes serious eye irritation' (H319) were noted. The International Fragrance Association (IFRA) imposes specific restriction limits for a related compound, ranging from 0.022% to 11% depending on product type and exposure, due to dermal sensitization and systemic toxicity concerns. The US EPA lists it as 'ACTIVE' under TSCA.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Due to a lack of specific clinical efficacy data for skincare benefits and documented concerns regarding dermal sensitization and irritation, the use of ETHOXY-METHOXYMETHYL-PHENOL as a skincare active is questionable.

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