Science
Mechanism of Action
While Ethiodized Oil is well-understood for its actions in medical contexts—functioning as a radiopaque contrast agent due to its iodine content and as an oily carrier for chemotherapeutics—there is no identified or established mechanism of action relevant to skin health or cosmetic purposes.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As an oil-based compound, Ethiodized Oil exhibits high solubility in organic solvents such as ethanol, chloroform, and ether, with minimal water solubility. Integration into aqueous cosmetic formulations would necessitate the use of an emulsifier. Specific stability data, including an optimal pH range for topical applications, is not documented.
Safety
Safety Profile
Ethiodized Oil holds FDA approval as a parenteral pharmaceutical product, administered via injection at a strength of 480 mg iodine per mL for medical imaging and therapeutic purposes. Its medical usage comes with significant warnings, including a boxed warning for embolism risk, and contraindications for hypersensitivity and hyperthyroidism. Critically, this regulatory status is for its drug application; it has not been reviewed by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for any cosmetic applications. Therefore, its safety profile as a topical cosmetic ingredient is largely unassessed.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to a complete absence of established cosmetic benefits and no safety assessment for topical application, combined with its primary role as a pharmaceutical agent with significant medical warnings, its use in skincare is not recommended.
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References
Sources