Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ERGOSTEROL ENDOPEROXIDE.

Questionable CAS 2061-64-5 / BLEACHING, HUMECTANT, SKIN CONDITIONING

Ergosterol Endoperoxide is a steroidal peroxide compound distinguished by its potent anti-inflammatory and antioxidant properties. Preclinical research indicates its capacity to mitigate cellular damage and suppress inflammatory responses, positioning it as a potentially beneficial ingredient in precision skincare formulations aimed at soothing irritation and combating oxidative stress.

Summary

Anti-inflammatory Antioxidant Immunosuppressive

Science

Mechanism of Action

This ingredient operates by modulating critical inflammatory pathways. It effectively suppresses the transcriptional activity of NF-kappaB and C/EBPbeta, while also inhibiting the phosphorylation of p38, JNK, and ERK MAPKs, all key regulators of inflammation. Additionally, Ergosterol Endoperoxide significantly reduces reactive oxygen species (ROS) levels in cells subjected to stressors such as UVA and LPS, contributing to its notable antioxidant profile.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Exhibited significant roles in mitigating inflammation and showed a more pronounced reactive oxygen species (ROS) scavenging effect than ergosterol in HaCaT cells damaged by UVA and LPS.
  2. 02 Topical application effectively reduced ear edema in a mouse model of inflammation.
  3. 03 Inhibited LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells, demonstrating its anti-inflammatory action.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Ergosterol Endoperoxide demonstrates poor aqueous solubility, estimated at 6.258e-005 mg/L at 25 °C, although it is more soluble than ergosterol itself due to additional oxygen atoms. Its aqueous solubility can be improved through the introduction of hydroxy and sulfate functional groups. It is soluble in methanol. The ingredient is highly sensitive to light and moisture, necessitating rigorous storage conditions such as -80°C for up to 6 months or -20°C for 1 month, indicating significant challenges for formulation stability in cosmetic products.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

There is no specific safety status for cosmetic use from CIR, SCCS, or FDA. General GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) found no specific hazards. Oral, dermal, and inhalation toxicity data for this compound are currently undetermined. An eye irritation test at 1 mg/mL suggested it could be potentially non-irritating or mildly irritating, but comprehensive dermal safety data for cosmetic application is lacking.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite demonstrating promising anti-inflammatory and antioxidant activities in preclinical studies, the lack of comprehensive safety data for dermal cosmetic use and significant formulation stability challenges render Ergosterol Endoperoxide a questionable ingredient for current precision skincare applications.

Related

Similar Ingredients

Finding similar ingredients…