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Moumoujus

EPOXIDIZED SOYBEAN OIL.

Insufficient Data CAS 8013-07-8 / PLASTICISER, SKIN CONDITIONING - EMOLLIENT

Epoxidized Soybean Oil (ESO) is a chemically modified derivative of natural soybean oil, where carbon-carbon double bonds are converted into reactive epoxide groups. While broadly used in various industries, its direct benefits and specific mechanisms for skin are not extensively detailed in dedicated skincare research.

Summary

Emollient Skin Conditioning Agent Antioxidant (via parent compound)

Science

Mechanism of Action

The mechanism of Epoxidized Soybean Oil (ESO) in skincare is largely inferred from its precursor, Glycine Soja Oil (soybean oil). Although specific skin-related biological activities for the epoxidized form are not comprehensively documented, the parent soybean oil is recognized for its emollient, moisturizing, and anti-aging properties. Soybean oil contributes essential fatty acids (linoleic acid, alpha-linolenic acid), ceramides, and beta-sitosterol, which are crucial for repairing the skin barrier and mitigating transepidermal water loss. It also contains antioxidant phenolic compounds (lecithins, lectins, isoflavones) that combat free radicals, and peptides with temporary wrinkle-smoothing potential. Industrially, ESO is primarily valued as a plasticizer and an acid scavenger, suggesting a potential stabilizing role in certain formulations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

As an oil, Epoxidized Soybean Oil is not prone to dusting.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Epoxidized Soybean Oil demonstrates stability under typical use conditions. It functions as an acid scavenger, indicating its epoxide groups can react with acids (e.g., phosphoric acid), leading to ring-opening hydrolysis and potential instability in highly acidic environments.

Conflicts

  • strong oxidizers
  • mineral acids
  • strong bases
  • reducing agents
  • amines

Safety

Safety Profile

CIR Status
Acknowledged within the broader category of soy-derived ingredients by the Cosmetic Ingredient Review (CIR), though a definitive individual safety status for Epoxidized Soybean Oil is not explicitly detailed in the available research.
Sensitization risk Low

Epoxidized Soybean Oil holds a Generally Recognized As Safe (GRAS) designation from the FDA (21 CFR 172.723) and is approved as an indirect food additive. The U.S. Environmental Protection Agency (EPA) assesses it as having low potential hazard to human health and the environment, citing its ready biodegradability. Safety data sheets generally classify it as 'not a hazardous substance or mixture.' However, direct contact may induce mild eye irritation, and prolonged skin exposure might lead to mild irritation or dermatitis. EWG Skin Deep® also assigns it 'LOW' concerns for categories including Cancer, Allergies & Immunotoxicity, and Developmental and Reproductive Toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Epoxidized Soybean Oil exhibits a favorable safety profile and derives from beneficial soybean oil, there is insufficient specific clinical data detailing its unique efficacy and mechanisms for direct skincare application.

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