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ELSHOLTZIA SPLENDENS EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Elsholtzia Splendens Extract is a botanical active exhibiting broad-spectrum benefits for skin, notably recognized for its anti-inflammatory, antibacterial, and antioxidant properties. This extract also shows promising effects in addressing common skin concerns such as acne, hyperpigmentation, and signs of aging.

Summary

Anti-inflammatory Antibacterial Antioxidant Anti-aging Skin brightening Sebum regulating Skin conditioning

Science

Mechanism of Action

This extract functions as a potent anti-inflammatory agent by actively inhibiting PGE2 production via cyclooxygenase-2 (COX-2) pathways. Its constituent compounds, such as luteolin, further reduce inflammation by downregulating nitric oxide (NO), TNF-α, IL-1β, IL-6, and NF-κB. It offers antibacterial protection against key skin pathogens including S. aureus, P. acnes, and S. epidermidis. Rich in phenolics like hesperidin, rutin, and quercetin, it provides antioxidant defense by neutralizing reactive oxygen species (ROS). Furthermore, the extract demonstrates potential for anti-aging through MMP-1 inhibition, skin brightening via tyrosinase inhibition, and sebum regulation through lipoxygenase inhibition.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Essential oils from Elsholtzia splendens were inhibitory against P. acnes, S. aureus, and S. epidermidis, with a Minimum Inhibitory Concentration (MIC) of 0.31 µL/mL against P. acnes, suggesting potential for acne treatment.
  2. 02 An oral 75% ethanol extract of Elsholtzia splendens at 400 mg/kg significantly inhibited mouse croton oil-induced ear edema (44.6% inhibition) and showed significant inhibitory activity against ear edema induced by multiple treatments of phorbol ester (a subchronic inflammation model).
  3. 03 Elsholtzia splendens extract significantly inhibited PGE2 production by pre-induced cyclooxygenase-2 (COX-2) of lipopolysaccharide-treated RAW 264.7 cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract contains volatile oils, which may require consideration for stability regarding light and air exposure during formulation to maintain efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Acute oral toxicity studies in mice showed no significant mortality or adverse clinical signs at doses up to 2000 mg/kg body weight/day for 15 days. It did not induce mutagenicity in bacterial reverse mutation assays (S. typhimurium and E. coli) at concentrations up to 5000 µg/plate. However, an in vitro chromosome aberration assay in Chinese Hamster Lung (CHL) cells showed an increased frequency of chromosomal aberration 22 hours after treatment at 5000 µg/mL without metabolic activation, suggesting a need for further study regarding potential genotoxic effects at high concentrations.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Elsholtzia Splendens Extract is a valuable botanical ingredient demonstrating a diverse range of potential benefits for skin health, including anti-inflammatory, antibacterial, and antioxidant actions, though further human topical efficacy and safety data are needed.

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