Science
Mechanism of Action
This botanical extract is rich in phenolics and flavonoids, which are broadly recognized for their capacity to neutralize free radicals (antioxidant activity) and mitigate inflammatory responses. In laboratory settings, specifically methanolic and aqueous forms of the extract have demonstrated potent antibacterial efficacy against bacterial species such as Proteus mirabilis and Klebsiella pneumoniae, implicated in certain autoimmune inflammatory conditions. The presence of moderate levels of alkaloids and tannins also contributes to its complex biochemical profile.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Duboisia leichhardtii plant itself is reported to be toxic to animals (cattle, horses, rats, dogs, cats, frogs) and humans, particularly in larger quantities or as an infusion of its leaves. The leaves are notably rich in potent tropane alkaloids, including scopolamine and hyoscyamine, which are pharmacologically active compounds. The Cosmetic Ingredient Review (CIR) has not assessed this ingredient, precluding a definitive safety profile for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite exhibiting potential antioxidant, anti-inflammatory, and antibacterial properties in vitro, the significant toxicity associated with the source plant due to potent alkaloids, coupled with a lack of CIR safety review, renders this ingredient highly questionable and generally advisable to avoid in precision skincare formulations.
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References
Sources