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Moumoujus

DOMIPHEN BROMIDE.

Avoid CAS 538-71-6 / ANTIMICROBIAL, ANTIPLAQUE, DEODORANT, ORAL CARE

Domiphen Bromide is a quaternary ammonium compound recognized for its broad-spectrum antimicrobial properties against bacteria, fungi, and certain viruses. It primarily functions by disrupting microbial cell membranes, leading to cellular content leakage and eventual cell death. Beyond its antiseptic action, it may also exhibit anti-inflammatory effects.

Summary

Antimicrobial Antiseptic Preservative Deodorant

Science

Mechanism of Action

As a quaternary ammonium compound, Domiphen Bromide exerts its antiseptic action by disrupting microbial cell membranes. Its positively charged nitrogen atom electrostatically interacts with negatively charged components of microbial cell membranes, such as phospholipids and proteins. This interaction leads to the disruption of the lipid bilayer, increasing membrane permeability, which results in the leakage of intracellular contents and ultimately microbial cell demise. It also interferes with essential enzyme activities and metabolic processes within microorganisms.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrates antiplaque, deodorant, and broad antimicrobial effects in oral care formulations at a 0.15% concentration.
  2. 02 An oral dosage of 0.5 mg administered every 4-6 hours significantly decreased pain and inflammation in acute infectious dental diseases within two days in a double-blind, placebo-controlled study.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Domiphen Bromide is hygroscopic and maintains stability under recommended storage conditions, requiring moisture avoidance. Aqueous solutions are clear, colorless, and foam profusely upon agitation. The pH of a 10% solution measures 6.42, a 1% commercial product solution at 25 °C is 5.5, and a 0.1% solution is 6.8.

Conflicts

  • Soaps (due to potential precipitation)
  • Other topical antiseptics or disinfectants (may enhance local irritative effects)
  • Dental care products containing fluoride or sodium lauryl sulfate (may affect antimicrobial activity)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has not reviewed Domiphen Bromide. While approved by European Union regulations for tooth care preparations, it is explicitly classified with Skin Irritation Category 2 and Eye Irritation Category 2, indicating potential for significant irritation. Precautions are advised against respiratory irritation. Use is contraindicated for individuals with known hypersensitivity to quaternary ammonium compounds. Application on large open wounds should be avoided due to the increased risk of systemic absorption. Extended use, particularly at higher concentrations, may lead to chronic localized irritation and can disrupt the skin's natural microbial balance. The Environmental Working Group (EWG) deems this ingredient 'unacceptable' for EWG VERIFIED™ products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its antimicrobial properties, Domiphen Bromide presents a high risk of skin and eye irritation, lacks comprehensive safety review for topical leave-on use, and is deemed unsuitable by environmental safety groups, making it inappropriate for precision skincare formulations.

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