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Moumoujus

DISPERSE ORANGE 3.

Avoid CAS 730-40-5 / HAIR DYEING

Disperse Orange 3 is an azo dye, primarily recognized for its use in textile and hair coloring. As a lipophilic disperse dye, it readily penetrates the skin, but its significant allergenic potential and association with contact dermatitis limit its suitability for precision skincare.

Summary

Colorant

Science

Mechanism of Action

Upon skin contact, Disperse Orange 3, a lipophilic substance, can be absorbed and subsequently hydrolyzed within the skin. This hydrolysis product, para-phenylenediamine (PPD), is a known potent sensitizer, directly contributing to the induction of contact dermatitis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted

Disperse Orange 3 is a potent contact allergen, frequently eliciting positive reactions even at concentrations used for diagnostic patch testing (1.0%). Its significant cross-sensitization potential with para-phenylenediamine (PPD) further elevates its risk, suggesting any intentional inclusion in leave-on skin products carries a very high probability of inducing sensitization.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This lipophilic dye is practically insoluble in water (290.7 µg/L at 25 °C) but exhibits solubility in various organic solvents such as ethanol, acetone, toluene, chloroform, DMSO, and methanol.

Conflicts

  • Potentially sensitizing for individuals allergic to para-phenylenediamine (PPD) due to cross-reactivity and hydrolysis in the skin.
  • Strong irritant to skin, eyes, and respiratory system.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

No specific CIR review or SCCS opinion for Disperse Orange 3 in cosmetic products for skin contact was found. OSHA considers it a hazardous substance. It may cause serious eye irritation and respiratory irritation. While there is limited evidence of a carcinogenic effect, it is not classified as carcinogenic or germ cell mutagenic. It is a known potent contact allergen, commonly linked to dermatitis from textile exposure and exhibiting strong cross-reactivity with para-phenylenediamine (PPD).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its significant sensitization potential, high irritancy, and lack of specific safety review for skin contact in cosmetics, Disperse Orange 3 should be avoided in precision skincare formulations.

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