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Moumoujus

DISPERSE BLUE 1.

Avoid CAS 2475-45-8 / HAIR DYEING

Disperse Blue 1 is a synthetic anthraquinone pigment primarily utilized as a colorant. This lipophilic compound is designed to integrate into various materials, including fibers, and exhibits some degree of skin absorption.

Summary

Hair Colorant Pigment

Science

Mechanism of Action

As a disperse dye, Disperse Blue 1 is characterized by its lipophilic nature, allowing it to dissolve within hydrophobic matrices. This property facilitates its uptake into materials such as synthetic fibers, and similarly, it can be absorbed through the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical assessments indicated no skin irritation observed at concentrations up to 10% in certain studies, though it is also reported as a moderate sensitizer.
  2. 02 In vitro studies at a 1% concentration demonstrated poor dermal penetration, with less than 0.15% absorbed through the skin.

Transparency

Dusting Analysis

Not commonly dusted

As a pigment whose use is heavily restricted by safety concerns and regulatory bans, Disperse Blue 1 is not subject to 'dusting' in the context of optimizing active ingredient percentages. Its application is strictly limited, or prohibited, based on safety profiles rather than efficacy thresholds.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The ingredient reportedly degrades above -20 °C, indicating significant instability at typical cosmetic product storage and use temperatures, posing considerable challenges for maintaining product integrity.

Conflicts

  • Acids (behaves as an amine, neutralizing acids)
  • Isocyanates
  • Halogenated organics
  • Peroxides
  • Phenols (acidic)
  • Epoxides
  • Anhydrides
  • Acid halides
  • Strong reducing agents (can generate flammable hydrogen)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Moderate

Disperse Blue 1 has been classified by the National Toxicology Program (NTP) and the International Agency for Research on Cancer (IARC) as 'possibly carcinogenic to humans' (Group 2B). It is recognized as a moderate sensitizer, mutagenic in multiple test systems, and can cause skin irritation and serious eye damage. Consequently, it is listed in Annex II of the EU Cosmetics Directive, prohibiting its use in cosmetic products due to its classification as a Category 2 Carcinogen (R45). Accidental ingestion carries the risk of methemoglobinemia.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Disperse Blue 1 is strongly advised against in skincare formulations due to its classification as a possible human carcinogen, demonstrated mutagenic activity, high irritancy, moderate sensitization risk, and its outright ban in European cosmetic products.

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