Science
Mechanism of Action
As a derivative of Ubiquinone (CoQ10), Disodium Ubiquinone functions as a powerful antioxidant by directly neutralizing damaging free radicals and mitigating oxidative stress within skin cells. This action helps to protect vital skin structures such as collagen and elastin. Beyond its direct antioxidant activity, it supports cellular energy production and can regenerate other crucial antioxidants, including Vitamin E, thereby enhancing the skin's intrinsic defense systems. Topical application visibly improves skin firmness, reduces the appearance of fine lines and wrinkles, and refines overall skin texture, alongside providing skin-soothing benefits.
Research
Clinical Evidence
Medium confidence0.05%
Key findings
- 01 Effective usage levels for Ubiquinone in skin are typically between 0.02% and 0.05%, demonstrating efficacy in combating visible environmental damage and reducing signs of aging.
- 02 Topical application of 1% Ubiquinone in olive oil to live rat skin resulted in dermal penetration, reaching concentrations of 8 µg/g after 2 hours and 15 µg/g after 4 hours.
- 03 A 2% complexed Ubiquinone (CoQ10) concentration in an anti-aging hyaluronic acid-vitamin C serum demonstrated favorable physicochemical properties, stability, and safety for topical skin application.
Transparency
Dusting Analysis
While the effective usage range for Ubiquinone is low (0.02-0.05%), and the reported maximum leave-on concentration is 0.05%, some complexed forms have been studied at higher percentages (e.g., 2%). Claims exceeding 0.05% for pure Disodium Ubiquinone without specific complexation or advanced delivery system justification could indicate 'dusting' or an ineffective concentration of the active ingredient.
The Formula
Formulation
Stability
Optimal stability for formulated Ubiquinone is achieved at a pH of 4.3 ± 0.2, closely matching the skin's natural acidity. Its inherent sparingly water-soluble nature necessitates complexation methods, such as with hydroxypropyl β-cyclodextrin, to enhance dispersibility in aqueous formulations.
Synergies
- Vitamin E (regenerates other antioxidants)
Conflicts
- Concentrations of 1% or higher may impart a noticeable yellow color to formulations.
- Potential for depigmentation and inhibition of tyrosinase activity at certain concentrations, requiring careful formulation to avoid these effects.
Safety
Safety Profile
The CIR Expert Panel deems Ubiquinone ingredients, including Disodium Ubiquinone, safe for cosmetic use within current practices and concentrations. Although Disodium Ubiquinone is not widely reported in cosmetic products (VCRP 2020, 2022), the broader Ubiquinone group has a reported maximum leave-on use concentration of 0.05% in body and hand products. All Ubiquinone ingredients are unrestricted under European Union cosmetic regulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Disodium Ubiquinone is a valuable antioxidant and anti-aging ingredient, well-tolerated across all skin types, effectively addressing oxidative stress and visible signs of aging with low irritancy.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources