Science
Mechanism of Action
This ingredient operates by modulating key enzyme activities and signaling pathways to reduce inflammation, specifically inhibiting 11-beta-hydroxysteroid dehydrogenase type 2, which increases local cortisol levels. It also downregulates pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. Furthermore, it exhibits antioxidant activity by scavenging free radicals and reactive oxygen species, and contributes to improved skin appearance by reducing flaking and enhancing suppleness.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Studies on structurally related compounds suggest potential stability challenges, such as phase separation, at very low pH (2-3), with optimal stability generally observed around a neutral pH of 7.
Safety
Safety Profile
The CIR Expert Panel has deemed Disodium Succinoyl Glycyrrhetinate and related licorice derivatives safe for cosmetic use under current practices, noting they are not irritants, sensitizers, phototoxic, or photosensitizers. These ingredients are poorly absorbed through the skin. While a specific maximum concentration for Disodium Succinoyl Glycyrrhetinate was not provided, related derivatives like Glycyrrhetinic Acid are deemed safe up to 2%. Contamination limits for PCBs/pesticides (max 40 ppm, with no single residue over 10 ppm) and toxic metals (arsenic 3 mg/kg, heavy metals 0.002%, lead 1 mg/kg) are recommended.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Disodium Succinoyl Glycyrrhetinate is a valuable ingredient, offering significant anti-inflammatory and antioxidant benefits, alongside skin conditioning properties, with a strong safety profile across all skin types.
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References
Sources