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Moumoujus

DISODIUM NADH.

Valuable CAS 606-68-8 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Disodium NADH is the reduced form of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme central to cellular energy metabolism. It functions as an electron donor, supporting crucial skin processes like cellular repair, collagen synthesis, and protection against oxidative stress, contributing to improved skin health and visible anti-aging benefits.

Summary

Skin conditioning Emollient Antioxidant support Collagen production boost Cellular repair and renewal Enhances skin resilience Supports anti-aging mechanisms Aids in skin hydration and elasticity

Science

Mechanism of Action

As a precursor to NAD+, Disodium NADH participates in fundamental cellular energy pathways, including glycolysis and the tricarboxylic acid (TCA) cycle, by donating electrons. Its conversion to NAD+ is essential for regulating metabolism, ATP production, and mitochondrial respiration. NAD+ also plays a critical role in managing reactive oxygen species, facilitating DNA repair, and activating sirtuins, which are key for collagen preservation in the dermis, supporting wound healing, and promoting keratinocyte proliferation for skin regeneration and resilience.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 11
0 7 14

Stability

Disodium NADH solutions are highly susceptible to oxidation and require storage under desiccated conditions, protected from light. For optimal stability, solutions should be prepared at concentrations not exceeding 5 mM within a pH range of 9.0 to 11.0, and stored at 4°C. Exposure to acidic media, specifically below pH 7.4, leads to rapid degradation.

Conflicts

  • Acids (particularly strong acids like L-ascorbic acid, due to significant pH instability and potential reduction in efficacy)
  • Salicylic acid (demonstrated to inhibit NADH oxidation)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Disodium NADH has not been reviewed by the CIR. However, NAD+, its metabolic product, is generally considered safe for cosmetic use, with typical topical product concentrations ranging from 0.5% to 20%. Some users may report infrequent, mild side effects such as tingling or slight redness, which can be influenced by individual skin sensitivity or product concentration. Environment Canada classifies Disodium NADH as 'not expected to be potentially toxic or harmful'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Disodium NADH is a valuable ingredient, offering substantial mechanistic support for cellular energy, repair, and anti-aging processes with broad skin benefits and good general compatibility, though direct topical clinical efficacy data for this specific form is currently limited.

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