Science
Mechanism of Action
Operating primarily as a surfactant, Disodium Isodecyl Sulfosuccinate effectively lowers the surface tension between different phases within a formulation. This action enables it to function as a wetting and dispersing agent, emulsifying oils with water, and contributing to the stability and texture of products while also conditioning the skin.
Research
Clinical Evidence
Medium confidence5%
Key findings
- 01 Safety assessments have largely extrapolated data from related dialkyl sulfosuccinates, such as Dioctyl Sodium Sulfosuccinate. A Repeated Insult Patch Test (RIPT) using a 5% concentration of Dioctyl Sodium Sulfosuccinate demonstrated no sensitization, though transient erythema was observed during the induction phase in certain subjects.
- 02 An earlier established safe limit of 0.42% for Diethylhexyl Sodium Sulfosuccinate was subsequently revised to 'safe as used in cosmetic formulations' in 1998, emphasizing careful formulation to prevent irritancy in products intended for prolonged skin contact.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Related sulfosuccinates are generally stable within a pH range of 4 to 9. However, highly acidic or alkaline conditions may induce hydrolysis, potentially breaking down the ester linkage.
Conflicts
- Highly acidic conditions (potential for hydrolysis)
- Highly alkaline conditions (potential for hydrolysis)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Disodium Isodecyl Sulfosuccinate, along with other dialkyl sulfosuccinate salts, 'safe in cosmetics in the present practices of use and concentration when formulated to be non-irritating'. This conclusion is based on extrapolated data from extensively studied related compounds. Formulators are advised that these surfactants can act as cumulative irritants, requiring careful formulation, especially for products intended for prolonged skin contact. While Disodium Isodecyl Sulfosuccinate lacks a specific FDA cosmetic status, a related compound, Dioctyl Sodium Sulfosuccinate, is FDA GRAS (Generally Recognized As Safe) for specific food and pesticide applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Disodium Isodecyl Sulfosuccinate is a valuable surfactant for cleansing and foaming formulations, provided it is carefully formulated within recommended concentrations to minimize its moderate irritancy potential.
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References
Sources