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Moumoujus

DISODIUM GUANYLATE.

Insufficient Data CAS 85-32-5 / 117-68-0 / 5550-12-9 / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Disodium Guanylate is a multifunctional ingredient recognized for its ability to enhance skin hydration and texture. It acts as both a humectant, drawing moisture to the skin, and an emollient, promoting a smooth and soft epidermal surface. Furthermore, it serves as a general skin conditioning agent, contributing to overall skin health and appearance.

Summary

emollient humectant skin conditioning

Science

Mechanism of Action

Disodium Guanylate operates through a dual mechanism, primarily functioning as a humectant to attract and retain water within the skin, thereby supporting optimal hydration levels. Concurrently, it acts as an emollient, forming a protective film on the skin's surface to smooth its texture and reduce transepidermal water loss, leading to a supple feel. Its comprehensive action also includes general conditioning, improving the skin's overall tactile quality.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Exhibits robust stability across a range of pH conditions. Notably, it possesses strong hygroscopic properties, capable of absorbing approximately 30% of its weight in water at 70% relative humidity, which is beneficial for maintaining formula integrity and skin hydration.

Conflicts

  • Potential for enzymatic degradation by phosphatase, a consideration for formulations where such enzymes may be present or active on the skin surface, though primarily observed in food applications.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While the Cosmetic Ingredient Review (CIR) and European Scientific Committee on Consumer Safety (SCCS) have not specifically reviewed Disodium Guanylate for skincare use, the ingredient holds 'Generally Recognized as Safe' (GRAS) status by the FDA and is approved as a food additive (E627) by EFSA. Its safety profile in food applications is considered robust, with minimal reported side effects, though dietary ingestion concerns exist for those with MSG sensitivity or conditions like gout due to purine metabolism. These dietary cautions are not directly transferable to topical skincare application, where specific dermal assessments are currently lacking.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While offering humectant and emollient properties, the current absence of dedicated skincare efficacy and safety assessments by relevant cosmetic bodies suggests a need for further data to fully ascertain its precision role in advanced formulations.

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