Science
Mechanism of Action
Disodium Glycyrrhizate modulates skin's inflammatory response primarily by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which increases local concentrations of active cortisol for anti-inflammatory effects. It also interferes with key pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, to mitigate inflammation and associated discomfort. Beyond its soothing actions, this ingredient acts as an antioxidant by scavenging free radicals and reactive oxygen species, and inhibits tyrosinase activity to reduce hyperpigmentation, contributing to skin-lightening.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Disodium Glycyrrhizate generally exhibits good stability within an optimal pH range of 4.0 to 8.0. Related glycyrrhizate compounds are stable at temperatures up to 121°C. However, formulation stability can be compromised in highly acidic environments below pH 4, potentially leading to gel formation. It is compatible with most non-ionic and anionic surfactant systems.
Conflicts
- Oxidizing agents
- Highly acidic environments (below pH 4)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded Disodium Glycyrrhizate, along with other glycyrrhizate salts and esters, is safe for use in current cosmetic practices. When derived from botanical sources, it is important to ensure that levels of pesticides and heavy metals (e.g., arsenic <3 mg/kg, lead <1 mg/kg) are below acceptable thresholds. This ingredient is not considered an irritant, sensitizer, phototoxic agent, or photosensitizer. While a specific maximum concentration for Disodium Glycyrrhizate itself is not specified, its close relative, Dipotassium Glycyrrhizate, is commonly used up to 1%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Disodium Glycyrrhizate is a valuable licorice root derivative offering significant anti-inflammatory, soothing, antioxidant, and skin-brightening benefits, suitable for all skin types and deemed safe for cosmetic use.
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