Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

DIPROPYLENETRIAMINE.

Avoid CAS 56-18-8 / BUFFERING

Dipropylenetriamine functions as an alkaline buffering agent in cosmetic formulations, capable of neutralizing acids. However, its application in skincare is significantly challenged by a high potential for irritation and a noted risk of forming carcinogenic nitrosamines under specific conditions.

Summary

Buffering

Science

Mechanism of Action

This compound acts as a buffering agent within cosmetic formulations. Its primary mechanism involves the neutralization of acidic components through exothermic reactions, resulting in the formation of salts and water.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The compound is sensitive to both air and light, and it is combustible. It exhibits basic properties, characterized by pKa values of 8.02 (diprotonated), 9.70 (monoprotonated), and 10.70 (unprotonated) at 30°C.

Conflicts

  • Isocyanates
  • Halogenated organics
  • Peroxides
  • Acidic phenols
  • Epoxides
  • Anhydrides
  • Acid halides
  • Oxidizing materials
  • Strong reducing agents (e.g., hydrides)
  • Nitrosating agents (due to potential nitrosamine formation)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The SCCS has highlighted concerns regarding Dipropylenetriamine's potential to generate nitrosamines in cosmetic products, particularly when in the presence of nitrosating agents and elevated temperatures. Its listing under FDA 21 CFR 176.180 pertains to indirect food additives, not direct cosmetic application safety. The ingredient has not been reviewed by the CIR.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its unreviewed safety status by the CIR, a high potential for skin irritation, and the significant risk of forming carcinogenic nitrosamines under common formulation conditions, Dipropylenetriamine is not recommended for use in skincare.

Related

Similar Ingredients

Finding similar ingredients…