Science
Mechanism of Action
This peptide operates by modulating a specific subunit of Protein Phosphatase 2A (PP2A), a critical holoenzyme integral to genomic stability, DNA repair, and senescence pathways. DIPEPTIDE-14 influences gene expression to arrest the cell cycle and improve DNA repair, thereby reducing the number of cells advancing to late senescence. It also effectively suppresses senescence by preventing the accumulation of late senescent cells and diminishing the Senescence-Associated Secretory Phenotype (SASP) through FoxO signaling.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In comprehensive 2D and 3D aged skin models, DIPEPTIDE-14 significantly reduced human dermal fibroblast senescence burden, irrespective of induction factors such as Hutchinson-Gilford Progeria Syndrome, chronological aging, UVB, or etoposide treatment, without inducing significant toxicity.
- 02 Studies on ex vivo human skin demonstrated that DIPEPTIDE-14 effectively reduced biological age, increased epidermal thickness, and notably improved various skin health markers.
- 03 The clinical outcomes observed with DIPEPTIDE-14 were superior to those achieved with Retinol, which is considered the gold-standard for anti-aging skin treatments.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptides, including DIPEPTIDE-14, are generally prone to chemical and physical instabilities such as hydrolysis, deamidation, and oxidation. For optimal stability, formulation in sterile buffers with a pH between 5-6 is recommended. Acid-catalyzed hydrolysis is prevalent at pH 1-3, while peptide backbone hydrolysis can occur within the 5-6 pH range. At pH levels exceeding 7, base-catalyzed epimerization becomes the primary degradation pathway. To preserve integrity, storage at -20°C or colder is advised, and repeated freeze-thaw cycles should be strictly avoided.
Conflicts
- Glycerol (due to potential condensation reactions with reactive aldehyde impurities)
- Substances that release aldehydes
- Moisture in combination with basic (alkalizing) agents in dry powder mixtures
Safety
Safety Profile
While DIPEPTIDE-14 specifically has not undergone formal safety assessment by CIR, SCCS, or FDA, clinical studies utilizing 'Peptide 14' indicated no significant toxicity and demonstrated a safe reduction of biological age in ex vivo human skin models. General considerations for peptide formulation stability apply.
Your Skin
Skin Compatibility
Our Assessment
Verdict
DIPEPTIDE-14 is a valuable active ingredient for precision skincare, demonstrating superior anti-aging and rejuvenating capabilities by directly targeting cellular senescence and enhancing DNA repair, with clinical efficacy surpassing Retinol.
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References
Sources