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DIOXOLANE.

Avoid CAS 646-06-0 / SOLVENT

Dioxolane, specifically 1,3-Dioxolane, is a cyclic acetal primarily utilized as an industrial solvent and chemical intermediate. It is explicitly not recommended for direct application in cosmetic or pharmaceutical formulations.

solvent

Science

Dioxolane does not possess a known mechanism of action or direct skincare benefits, as it is not designed for or recognized as an active cosmetic ingredient.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

1,3-Dioxolane is specifically indicated as 'Not for direct use in food, cosmetics and or pharmaceuticals', hence it is not an ingredient typically 'dusted' in cosmetic applications.


The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

1,3-Dioxolane can act as a base and reacts with strong acids, forming salts. Its cyclic acetal structure renders it susceptible to acid-catalyzed hydrolysis or transacetalization, indicating instability under acidic conditions. Optimal storage stability is achieved below 4°C.

Conflicts

  • strong oxidizing agents
  • strong acids

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

1,3-Dioxolane is expressly labeled as 'Not for direct use in food, cosmetics and or pharmaceuticals'. Consequently, there is no approved maximum concentration for cosmetic inclusion, and the Cosmetic Ingredient Review (CIR) has not evaluated its safety for cosmetic use. It is critical to differentiate 1,3-Dioxolane from 1,4-Dioxane, a common trace contaminant in some cosmetic products, which is monitored by regulatory bodies like the SCCS and FDA, with trace levels (≤10 ppm) generally considered safe.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Avoid

Due to its explicit designation as 'Not for direct use in cosmetics' and a complete absence of recognized skincare benefits or specific safety data for dermal application, Dioxolane should be avoided in cosmetic formulations.


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