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DIMETHYL OXAZOLIDINE.

Avoid CAS 51200-87-4 / PRESERVATIVE

DIMETHYL OXAZOLIDINE functions primarily as a broad-spectrum preservative within cosmetic formulations. Its mechanism involves the controlled release of formaldehyde, which serves to inhibit microbial proliferation and maintain product integrity.

Preservative Formaldehyde Releaser

Science

DIMETHYL OXAZOLIDINE acts as a preservative by undergoing hydrolysis in aqueous solutions, thereby gradually releasing formaldehyde. This released formaldehyde then binds to residual water molecules and effectively disrupts the growth of various microorganisms, including slime-forming bacteria and fungi, safeguarding the product's stability.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Commonly dusted
Min. effective
0.1%
Red flag below
0.1%

Given its classification as a formaldehyde releaser and the documented risks of skin sensitization and irritation, DIMETHYL OXAZOLIDINE is frequently avoided in precision skincare formulations. The maximum authorized concentration in the EU is 0.1%, a threshold that underscores its potential for adverse effects if exceeded or even within the allowed range for sensitive individuals.


The Formula

Solubility
Water
Optimal pH ≥6
0 7 14

Stability

This compound exhibits stability under dry, neutral conditions. However, in acidic environments or aqueous solutions, it hydrolyzes, reverting to its precursor amine and aldehyde components while releasing formaldehyde.

Conflicts

  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
0.1%
Sensitization risk High

Identified as a formaldehyde releaser, the primary consumer health concern is skin sensitization due to the released formaldehyde. It is also reported as a severe eye irritant and can cause skin irritation. In the EU, it is allowed as a preservative at a maximum authorized concentration of 0.1% in products with a pH greater than 6 (Annex V of Regulation (EC) No 1223/2009).


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

Due to its classification as a formaldehyde-releasing agent, high risk of skin sensitization and irritation, and an INCIDecoder rating of 'avoid', this ingredient is not recommended for precision skincare formulations.


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