Science
Mechanism of Action
Dimethyl Dicaproyl Cystinate functions by inhibiting the nuclear translocation of NF-κB and reducing the secretion of IL-1α in human keratinocytes (HaCaT cells) following UVB radiation, indicating an anti-inflammatory effect. It also modulates immune responses by decreasing lymphocyte proliferation and the release of pro-inflammatory cytokines like IFN-γ and IL-2. The compound's involvement in disulfide bond chemistry suggests a role in cellular redox regulation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Dimethyl Dicaproyl Cystinate is primarily identified as a research chemical or an intermediate in pharmaceutical synthesis rather than a direct cosmetic active. Consequently, 'dusting' (inclusion in formulations at ineffective, low concentrations) is not a common concern for this ingredient in cosmetic products.
The Formula
Formulation
Stability
The raw material exhibits limited solubility in aqueous solutions (sparingly soluble in PBS at pH 7.2, 1-10 mg/ml), but is readily soluble in organic solvents such as DMSO (≥ 10 mg/ml). For raw material storage, it is recommended to keep it dry, dark, and at 0-4°C for short-term preservation or -20°C for long-term stability.
Safety
Safety Profile
Dimethyl Dicaproyl Cystinate has not undergone specific safety reviews by major cosmetic regulatory bodies such as the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). It is predominantly recognized as a research chemical or an intermediate for pharmaceutical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite exhibiting promising anti-inflammatory and immunomodulatory activities in in vitro and limited in vivo animal studies, the absence of dedicated cosmetic safety reviews, human clinical data, and its primary classification as a research chemical render the data insufficient for a definitive cosmetic recommendation.
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References
Sources