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Moumoujus

DIMETHYL DIACETYL CYSTINATE.

Insufficient Data CAS 139612-43-4 / HAIR CONDITIONING

A derivative of L-cystine, Dimethyl Diacetyl Cystinate is an immunomodulatory agent known for its ability to influence cellular redox balance. It exhibits preclinical potential in mitigating inflammatory responses and oxidative stress, particularly in skin cells exposed to environmental stressors.

Summary

Antioxidant Anti-inflammatory Immunomodulatory Redox balancer

Science

Mechanism of Action

Dimethyl Diacetyl Cystinate operates by effectively inhibiting the nuclear translocation of NF-κB and the secretion of IL-1α, key mediators of inflammation, in HaCaT keratinocyte cells following UVB radiation. This action is attributed to an increase in intracellular reducing capacity, which shifts the cellular redox state to one less conducive to NF-κB activation, potentially modulating its DNA binding activity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibits UVB radiation-induced NF-κB nuclear translocation and IL-1α secretion in HaCaT keratinocyte cells, indicating anti-inflammatory potential.
  2. 02 Decreases lymphocyte proliferation and reduces the secretion of IFN-γ and IL-2 in lymphocyte co-cultures, suggesting immunomodulatory effects.
  3. 03 Reduces corneal glutathione (GSH) levels and enhances corneal allograft survival in mice, pointing to antioxidant and immunoregulatory functions in vivo.

Transparency

Dusting Analysis

Not commonly dusted

No data is available to suggest this ingredient is commonly 'dusted' or used at concentrations significantly below its efficacious range for marketing purposes.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The compound demonstrates long-term stability (≥ 4 years) when stored at -20°C. For shorter durations (days to weeks), dry, dark storage between 0-4°C is recommended. It exhibits solubility in DMSO (≥10 mg/mL) and is sparingly soluble in PBS (pH 7.2) (1-10 mg/mL).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Dimethyl Diacetyl Cystinate is primarily designated for research use and has not undergone formal safety assessment for cosmetic applications by standard regulatory bodies like CIR or SCCS. While it is listed in the FDA Global Substance Registration System (GSRS) and serves as a highly characterized reference material in drug applications (ANDA, NDA) and Acetylcysteine production, this does not imply cosmetic safety or efficacy.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Dimethyl Diacetyl Cystinate presents intriguing preclinical data suggesting anti-inflammatory and antioxidant benefits, yet its lack of formal cosmetic safety assessment and human skin efficacy studies means there is insufficient data for routine skincare application.

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