DIISOPROPYLAMINE.

The Cosmetic Ingredient Review (CIR) Expert Panel concluded Diisopropylamine is safe for cosmetic use as presently formulated, with the critical restriction that it must not be used in products containing N-nitrosating agents to prevent the formation of carcinogenic nitrosamines. While direct dermal application of the raw ingredient can cause irritation due to its high alkalinity, this effect is largely mitigated within a properly formulated and pH-neutralized cosmetic product. It is, however, considered an ocular irritant. Notably, the European Union's Cosmetics Directive reportedly bans or considers Diisopropylamine unsafe for use in cosmetics, presenting a key divergence from the CIR's qualified safety assessment. No specific SCCS opinion was found in available data. In the U.S., cosmetic ingredients do not require pre-market FDA approval, although the CIR process includes FDA participation.