Science
Mechanism of Action
As a chelating agent, diisopropyl oxalate acts by complexing with metal ions, thereby neutralizing their reactivity within a formulation. This action can mitigate undesirable reactions, such as oxidation, which are often catalyzed by metal impurities, ultimately contributing to the product's stability and shelf-life.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Diisopropyl oxalate is practically insoluble in water, possessing a low water solubility (log10WS -1.12), but readily dissolves in organic solvents. With moderate lipophilicity (logPoct/wat 0.890), this ester is susceptible to hydrolysis in aqueous conditions, particularly under extreme acidic or basic pH levels, which can lead to degradation. Furthermore, it may react violently when combined with strong oxidizing agents.
Conflicts
- strong oxidizing agents
- strong acids
- strong bases
Safety
Safety Profile
This ingredient is associated with GHS hazard statements H315: Causes skin irritation and H319: Causes serious eye irritation. The EWG Skin Deep database notes high use restrictions, and critically, diisopropyl oxalate is restricted for use in cosmetics by the EU Cosmetics Directive, indicating significant regulatory and safety concerns.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its high irritancy, documented GHS hazard statements, explicit restriction within the EU Cosmetics Directive, and unreviewed CIR safety status, diisopropyl oxalate is deemed unsuitable and should be avoided in precision skincare formulations.
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References
Sources