Science
Mechanism of Action
This compound acts as a powerful antimicrobial by inhibiting the proliferation of a wide range of microorganisms, including bacteria, fungi, and algae. In skincare formulations, its primary mechanism is to prevent product spoilage and maintain hygienic conditions by actively controlling microbial and fungal contamination.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Identified by CFTA/INCI as an approved fungicide (under the designation AMICAL™ preservative) for cosmetic preservation, it is recognized for its high effectiveness in controlling microbial and fungal degradation in various applications.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Diiodomethyltolylsulfone demonstrates efficacy across a broad pH range, from 2 to 11. It remains stable to hydrolysis at pH 5 but experiences degradation at pH 7 and 9, with half-lives ranging from 1.5 to 9.6 days. Its extremely low water solubility (less than 5 ppm to 10 mg/L) presents a formulation challenge, often requiring its integration as a particulate dispersion within a liquid solvent for optimal chemical compatibility.
Safety
Safety Profile
While a specific Cosmetic Ingredient Review (CIR) assessment is not available, diiodomethyltolylsulfone is classified as a low dermal irritant (Toxicity Category IV) and is not considered a dermal sensitizer, described as non-dermally irritating. However, it is classified as an eye corrosive (Toxicity Category I), necessitating careful handling during manufacturing and formulation. The ingredient holds FDA clearance for several indirect food contact applications and is EPA-registered for various industrial preservative uses.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Diiodomethyltolylsulfone is a valuable preservative, crucial for ensuring the microbial stability and shelf-life of cosmetic products, though its low water solubility and classification as an eye corrosive necessitate precise and careful formulation strategies.
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References
Sources