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DIHYDROXYPROPYL HYDROLYZED CASEIN.

Valuable CAS - / HAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Dihydroxypropyl Hydrolyzed Casein is a modified derivative of casein, meticulously engineered to enhance skin hydration and barrier function. This ingredient actively works to improve the skin's natural moisture retention, concurrently offering antioxidant and anti-inflammatory benefits.

Summary

Natural Moisturizing Factor Support Humectant Skin Barrier Support Antioxidant Anti-inflammatory Pigmentation Reduction Skin Conditioning

Science

Mechanism of Action

This ingredient functions as a natural moisturizing factor (NMF) by facilitating water retention within the skin and reinforcing the epidermal barrier through its influence on stratum corneum lipid synthesis. Its casein-derived peptides demonstrate antioxidant and anti-inflammatory properties. Furthermore, general casein hydrolysates have been observed to mitigate facial pigmentation by reducing the accumulation of Advanced Glycation End Products (AGEs). The specific dihydroxypropyl modification is believed to amplify its humectant capabilities and substantivity for both skin and hair.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7
0 7 14

Stability

Hydrolyzed casein, post-enzymatic cleavage, exhibits enhanced water solubility compared to native casein due to reduced molecular size and increased ionizable groups. While stable within a pH range of 5.5 to 7.0 for at least 4 weeks, formulators should note its reduced solubility near its isoelectric point around pH 4.6, with potential precipitation or diminished stability observed between pH 4.0 and 5.0 unless specifically stabilized.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
2%
Sensitization risk Low

The CIR Expert Panel concluded that 'Bovine Milk Proteins and Protein Derivatives', including Hydrolyzed Casein, are safe for cosmetic use. Safety assessments for Hydrolyzed Casein at concentrations up to 30% showed no ocular or dermal irritation or sensitization. Although bovine milk proteins are known food allergens, the risk of Type I hypersensitivity from topical cosmetic application is considered unlikely. It is generally recognized as safe (GRAS) by the U.S. FDA, with a maximum reported cosmetic use concentration of 2% in leave-on products.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dihydroxypropyl Hydrolyzed Casein is a valuable multifunctional ingredient, offering significant hydration, barrier support, and antioxidant benefits, suitable for a wide range of skin types with a low risk of irritation or sensitization.

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