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Moumoujus

DIHYDROXYINDOLINE.

Insufficient Data CAS 29539-03-5 / HAIR DYEING

Dihydroxyindoline acts as a melanin precursor, primarily utilized in hair dye formulations. It participates in oxidative reactions to produce color resembling natural melanin.

Summary

Melanin precursor

Science

Mechanism of Action

This compound exhibits melanin mimetic properties. In biological processes, 5,6-dihydroxyindole (DHI), a related compound, is formed from dopachrome and oxidizes to produce eumelanin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 European Commission SCCNFP/0669, final
  2. 02 European Commission SCCNFP/0657/03, final

Transparency

Dusting Analysis

Not commonly dusted

Its primary use is in hair dye formulations where controlled application is essential; no evidence suggests common dusting in skincare.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 7
0 7 14

Stability

5,6-Dihydroxyindoline hydrobromide is stable between pH 3.5-7. Dihydroxyindole is highly oxygen-sensitive and needs protection from light and inert atmosphere.

Conflicts

  • Exposure to oxygen (due to rapid oxidation)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Unknown

The SCCNFP evaluated Dihydroxyindoline HBr for hair dyes at a maximum of 2%. No CIR review or direct FDA status for its use in skincare was found.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

The current research focuses on Dihydroxyindoline's role in hair dyes; its efficacy and safety for topical skincare applications are not well-documented.

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References

Sources