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Moumoujus

DIHYDROXYINDOLE.

Avoid CAS 3131-52-0 / HAIR DYEING

Dihydroxyindole (DHI) is a melanin precursor, vital for eumelanin synthesis in skin and hair, and functions as a hair colorant. It rapidly oxidizes upon air exposure, forming dark polymers.

Summary

Melanin Precursor Hair Colorant Antioxidant Bactericidal

Science

Mechanism of Action

DHI serves as an intermediate in eumelanin biosynthesis, spontaneously forming from dopaquinone. It polymerizes with atmospheric oxygen, offering hair coloring properties without additional oxidants, and also exhibits antioxidant and bactericidal effects.

Research

Clinical Evidence

Low confidence
Effective range 0.5–5%
Optimal

0.5%

Transparency

Dusting Analysis

Not commonly dusted

Dihydroxyindole is primarily used in hair coloring, not typically dusted for skincare, and presents significant stability challenges due to rapid oxidation.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Highly sensitive to oxygen and light, rapidly oxidizing to a melanin-like substance in solution. Stability in products is a major concern and poorly characterized.

Conflicts

  • oxygen
  • light
  • alkaline conditions (promotes oxidation/polymerization)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

SCCNFP deemed it unsuitable for hair dyes, and SCCP raised concerns about mutagenicity/genotoxicity and inadequate safety margins. EWG notes high use restrictions and irritancy, with EU classifying it under restricted use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant safety concerns, EU use restrictions, and classification as an irritant, Dihydroxyindole is not recommended for cosmetic use.

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