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DIHYDROXYACETIC ACID.

Avoid / ANTISTATIC, BUFFERING, HAIR WAVING OR STRAIGHTENING

Dihydroxyacetic Acid, commonly referred to as Glyoxylic Acid, is an alpha-oxo acid found in various cosmetic formulations. While it possesses exfoliating and skin-brightening properties, its use is associated with significant health concerns, particularly acute renal failure.

Antistatic pH regulator Hair waving or straightening Exfoliant Skin-brightening agent

Science

This alpha-oxo acid works by promoting cell turnover to exfoliate and brighten skin. In hair care, it chemically modifies hair keratin to smooth frizz and add shine, especially when heat-activated.


Research

Low confidence
Effective range 0.5–10%
Optimal

N/A

Key findings

  1. 01 No specific clinical study findings for direct skin benefits are available.

Transparency

Not commonly dusted

This ingredient is not commonly 'dusted' for skin benefits. Severe safety warnings, including renal failure risk and irritancy, significantly outweigh any minor potential skin benefits.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Glyoxylic acid monohydrate is hygroscopic, absorbing environmental moisture. It can react with nucleophiles, and its optimal pH range for stability in cosmetic formulations is not explicitly provided.

Conflicts

  • Substances that react with aldehydes or carboxylic acids
  • Nucleophiles
  • Formaldehyde releasers
  • May cause acute renal failure; products containing it should be avoided

Safety

CIR Status
Not reviewed
Sensitization risk High

French researchers link topical use to acute renal failure from oxalate crystal accumulation, advising product withdrawal. It is corrosive, an irritant to skin, eyes, and respiratory system, and releases formaldehyde.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

Due to overwhelming safety concerns, including a risk of acute renal failure and its nature as a formaldehyde releaser and irritant, Dihydroxyacetic Acid should be avoided in all cosmetic formulations.


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