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Moumoujus

DIETHYLENE GLYCOL DIMETHACRYLATE.

Avoid CAS 2358-84-1 / FILM FORMING, NAIL CONDITIONING

Diethylene Glycol Dimethacrylate (DEGDMA) is a hydrophilic crosslinking acrylate monomer primarily utilized in polymer synthesis to enhance mechanical strength and stability. However, its unpolymerized form is known to exhibit cytotoxic and genotoxic effects.

Summary

Science

Mechanism of Action

DEGDMA functions as a cross-linking agent, providing mechanical strength and thermal stability to polymers. Its adverse cellular effects, including increased reactive oxygen species and DNA damage, arise from unpolymerized monomers.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This compound is light-sensitive and requires storage at -20°C. Stabilization with inhibitors, such as ~500 ppm MEHQ, is crucial to prevent premature polymerization.

Conflicts

  • Exothermic polymerization
  • Release of cytotoxic/genotoxic monomers from incomplete polymerization
  • Metallic copper (requires specific stabilization)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Classified as a moderate skin sensitizer, DEGDMA is also an irritant to skin, eyes, and respiratory system. Its unpolymerized form is cytotoxic and genotoxic; CIR and FDA cosmetic safety status are currently unreviewed.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

This ingredient is unsuitable for skincare due to its classification as a moderate sensitizer and irritant, significant cytotoxic and genotoxic risks from unpolymerized monomers, and unreviewed safety status for cosmetic use.

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