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Moumoujus

DIETHYLAMINE.

Avoid CAS 109-89-7 / BUFFERING, FRAGRANCE, PERFUMING

Diethylamine functions as a pH regulator and is utilized for masking or perfuming in various formulations. It also acts as a skin penetration enhancer, primarily in pharmaceutical applications to boost active ingredient delivery.

Summary

pH regulator masking agent perfuming agent skin penetration enhancer

Science

Mechanism of Action

It increases the permeability of the skin, thereby facilitating deeper tissue penetration of co-formulated active ingredients. This mechanism has been observed with compounds like diclofenac diethylamine.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 When formulated as a 1.16% diclofenac diethylamine emulsion, it significantly enhanced diclofenac permeation through human skin compared to a standard gel, indicating its role in improving topical drug delivery.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Diethylamine is highly reactive and strongly alkaline, sensitive to heat and prolonged air exposure. Proper storage is crucial to prevent undesired reactions, particularly with oxidizing agents.

Conflicts

  • strong acids
  • oxidizing agents
  • cellulose nitrate
  • some metals
  • dicyanofuroxan
  • nitrous acid
  • nitrates
  • atmospheres with high nitrous oxide concentrations
  • nitrosating agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

This strongly alkaline, corrosive liquid causes significant irritation and burning to the eyes, skin, and respiratory system. A critical concern is its potential to form N-nitrosamines, potent carcinogens, when exposed to nitrosating agents.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its corrosive nature, high irritation potential, and significant risk of forming carcinogenic N-nitrosamines, diethylamine is deemed unsuitable for Moumoujus skincare formulations.

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