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DIETHYL ASCORBIC ACID.

Valuable CAS 277325-36-7 / SKIN CONDITIONING

Diethyl Ascorbic Acid is a highly stable, etherified vitamin C derivative known for its excellent skin penetration. It offers potent antioxidant, brightening, and anti-aging benefits for a revitalized complexion.

Antioxidant Skin brightening Anti-aging Anti-inflammatory Collagen booster

Science

Absorbed into the skin, it metabolizes into pure L-ascorbic acid, scavenging free radicals and stimulating collagen synthesis. It effectively inhibits melanin production through multiple pathways, reducing dark spots and improving overall skin tone.


Research

High confidence
Effective range 0.5–30%
Optimal

N/A

Key findings

  1. 01 Observed benefits include skin brightening and age management.
  2. 02 Clinical in-vivo data showed improved skin tone and whitening effects.
  3. 03 In-vitro studies revealed excellent skin brightening activity by reducing melanin.
  4. 04 Demonstrated photoprotective potential (24% reduction in γ-H2AX positive cells) and significant anti-ageing effects, boosting collagen production by over 1000%.

Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH 3.5 – 6.5
0 7 14

Stability

A very stable vitamin C derivative, it maintains optimal stability and skin compatibility between pH 3.5 and 6.5, ideally pH 4.0-5.5. It should be stored below 25°C in dark conditions.

Synergies

  • Vitamin E
  • Ferulic acid
  • Chelating agents (e.g., EDTA)
  • Buffer systems (e.g., citric acid, sodium citrate)

Conflicts

  • pH below 5.0 (potential skin irritation)
  • pH above 6.5 (reduced stability and efficacy)

Safety

CIR Status
Insufficient data
Sensitization risk Low

The CIR Expert Panel found insufficient specific data for Diethyl Ascorbic Acid's safety, though L-ascorbic acid and its ascorbates are generally considered safe. It is recognized as a cosmetic raw material by Korea FDA (2001) and China FDA (2021).


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Diethyl Ascorbic Acid is a valuable, stable vitamin C derivative offering comprehensive benefits for brightening, anti-aging, and skin protection, suitable for all skin types.


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