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DIETHOXYDIGLYCOL.

Valuable CAS 112-36-7 / SOLVENT

DIETHOXYDIGLYCOL is a versatile solvent and carrier that enhances the delivery of active ingredients into the skin. It also functions as a humectant, attracting and retaining moisture for improved skin hydration.

Solvent Humectant Penetration Enhancer Carrier Viscosity Controlling

Science

It primarily acts as a penetration enhancer, temporarily modifying the skin barrier to improve the absorption of other active ingredients. Additionally, it functions as a humectant, drawing moisture to the skin surface.


Research

High confidence
Effective range 1–10%
Optimal

N/A

Key findings

  1. 01 Typically used at 1-10% in cosmetic formulations to improve ingredient function, penetration, and humectant benefits.
  2. 02 Formulated in FDA-approved topical products up to 49.9% (marketed as Transcutol®).

Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH 3 – 7
0 7 14

Stability

This ingredient is stable, hygroscopic, and heat tolerant, enhancing emulsion stability and reducing viscosity. It is light-sensitive and should be added to the water phase.

Synergies

  • Enhances the efficacy and absorption of various active ingredients by improving their delivery into the skin.

Conflicts

  • No direct incompatibilities with specific skincare ingredients have been consistently reported.

Safety

CIR Status
Safe as used
Max tested
2.6%
Sensitization risk Low

Both CIR and SCCS deem it safe for cosmetic use, with SCCS allowing up to 2.6% in leave-on formulations. It is also FDA-compliant, used in pharmaceutical products up to 49.9%.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A valuable multi-functional ingredient known for significantly improving the penetration of active compounds, hydrating the skin, and stabilizing formulations.


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