Science
Mechanism of Action
This extract scavenges various free radicals (DPPH, H2O2, •OH) due to its rich phytochemical profile, including flavonoids. It also exhibits anti-inflammatory effects by suppressing pro-inflammatory cytokines and improves skin barrier integrity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro, it increased cell proliferation by 112.78% at 3.25 µg/mL.
- 02 Demonstrated in vitro antioxidant activity, inhibiting DPPH radicals (IC50 38.20 ± 0.46 µg/mL) and removing H2O2 (IC50 912 ± 40 µg/mL).
- 03 Topical application of a related species (Dictamnus dasycarpus) in mice alleviated skin lesion severity, improved skin water content, and reduced inflammatory cytokines in atopic and contact dermatitis models.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Plant extracts can be sensitive to environmental factors like temperature, pH, oxygen, and light, potentially affecting active compound stability. It is likely water-soluble.
Safety
Safety Profile
No specific safety assessment by CIR or SCCS exists. While higher in vitro concentrations showed toxicity and general Dictamnus species may have phototoxic potential, no direct topical human data for this root extract is available.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Dictamnus Albus Root Extract is a valuable ingredient for its antioxidant, anti-inflammatory, and skin barrier-supporting properties, though further human topical efficacy and safety data would strengthen its profile.
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References
Sources