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DIAZOLIDINYL UREA.

Valuable CAS 78491-02-8 / PRESERVATIVE

A synthetic antimicrobial preservative effective against a broad spectrum of microorganisms, it extends product shelf life by preventing microbial spoilage.

Antimicrobial Preservative Formaldehyde Releaser

Science

Functions by slowly releasing formaldehyde, which disrupts microbial cell functions. This ensures product integrity and safety over time.


Research

High confidence
Effective range 0.1–0.5%
Optimal

0.2%

Key findings

  1. 01 Optimal preservative efficacy against bacteria, yeast, and mold achieved at 0.1-0.3%.
  2. 02 Antimicrobial activity demonstrated at 0.3% against P. aeruginosa, S. marcescens, and S. epidermidis.
  3. 03 A 1990 study indicated mild cumulative skin irritation up to 0.4%.

Transparency

Commonly dusted
Min. effective
0.4%
Red flag below
0.5%

While effective at low concentrations, exceeding 0.4% can cause mild skin irritation. The maximum authorized 0.5% showed in vitro erythrocyte toxicity, indicating potential risks with overuse.


The Formula

Solubility
Water
Optimal pH 0.3 – 9
0 7 14

Stability

Highly stable across a wide pH range (0.3-9.0) and temperatures up to 100°C. Best incorporated into the water phase during cool-down below 60°C for maximal efficacy.

Conflicts

  • Oxidizing agents
  • Other formaldehyde-releasing agents
  • Ingredients that form nitrosamines (above 10°C)

Safety

CIR Status
Safe with restrictions
Max tested
0.5%
Sensitization risk Moderate

CIR and SCCS deem it safe below 0.5% due to low formaldehyde release. However, it's a known formaldehyde-releasing preservative and can cause skin sensitivities like irritation and redness in susceptible individuals.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Valuable

A highly effective broad-spectrum preservative essential for product stability and microbial safety when used within strict concentration limits, though potential for sensitivity exists.


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