Science
Mechanism of Action
DADS boosts key antioxidant and detoxification enzymes such as glutathione S-transferase and catalase, thereby reducing oxidative stress. It also modulates inflammatory pathways, including PKB and ERK1/2 signaling, and induces phase II enzymes.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In vitro, DADS reduced deoxycholic acid-induced reactive oxygen species (ROS) in Barrett's epithelial cells (effective concentration range).
- 02 Pretreatment at 40 μM (in vitro) hindered A549 lung cancer cell proliferation and migration.
- 03 However, concentrations above 50 μM (in vitro) increased free radicals, membrane lipid peroxidation, and showed cytotoxicity at 100 μM.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Slightly soluble in aqueous buffers; aqueous solutions are unstable beyond one day. It is temperature-sensitive, converting rapidly above 37°C, and oxidizes easily in the presence of strong oxidizing agents like peracetic acid or hydrogen peroxide. Stock solutions require purging with inert gas.
Conflicts
- Peracetic acid
- Hydrogen peroxide
- Strong oxidizing agents
Safety
Safety Profile
Diallyldisulphide is classified as a Skin Irritant Category 2 and a significant allergen, identified as the primary cause of garlic allergic contact dermatitis. In vitro, concentrations above 50 μM demonstrated cellular toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising in vitro antioxidant and anti-inflammatory benefits, Diallyldisulphide is a known skin irritant and significant allergen, making it unsuitable for precision skincare formulations due to high sensitization risk.
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References
Sources