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Moumoujus

DESMODIUM GANGETICUM ROOT EXTRACT.

Valuable CAS 92201-58-6 / SKIN CONDITIONING

A potent botanical extract derived from a cornerstone Ayurvedic herb, valued for its complex phytochemical profile that provides multi-pathway defense against environmental stressors. It serves as a high-performance skin conditioner that targets oxidative damage and microbial imbalance simultaneously.

Summary

Antioxidant Soothing agent Antimicrobial Skin conditioning

Science

Mechanism of Action

This extract operates through a synergistic blend of flavonoid glycosides, pterocarpanoids (such as gangetin and desmodin), and phenolic derivatives. These bioactive compounds neutralize reactive oxygen species and inhibit pro-inflammatory mediators, while its antimicrobial components disrupt the growth cycles of bacteria like S. aureus and P. aeruginosa, helping to maintain a balanced skin microbiome.

Research

Clinical Evidence

Medium confidence
Effective range 2.5–10%
Optimal

N/A

Key findings

  1. 01 In vitro analysis (2023) confirmed significant growth inhibition against Escherichia coli and Staphylococcus aureus at concentrations between 2.5-10 mg/mL.
  2. 02 Pharmacological reviews (2025) identified a total antioxidant capacity of 149.91% relative to ascorbic acid, demonstrating superior radical scavenging via DPPH and NO assays.
  3. 03 In vivo rat models showed up to 51.02% protection against induced inflammation using aqueous decoctions.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.25%
Red flag below
0.05%

Frequently included in 'Ayurvedic' or 'natural' marketing blends at trace amounts (often <0.1%). To reach the 2.5 mg/mL threshold observed in antimicrobial studies, the extract must be present at significant levels rarely found in mass-market formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Contains both polar (water/alcohol) and non-polar (hexane-soluble) bioactive fractions. Stability can be challenging; some preparations may present aesthetic issues or precipitation if the carrier system is not precisely balanced.

Synergies

  • Ascorbic Acid
  • Vitamin E
  • Soothing botanical extracts

Conflicts

  • Known irritants
  • Highly acidic formulas (potential precipitation)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While oral toxicity is extremely low (7g/kg in mice), topical application carries a likelihood of irritation, particularly when combined with other reactive ingredients. No formal CIR or FDA safety assessment for cosmetic use currently exists.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

A high-potential botanical with antioxidant capacity exceeding Vitamin C in laboratory tests, though it requires careful formulation to avoid potential topical irritation.

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