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Moumoujus

DENATONIUM SACCHARIDE.

Avoid CAS 90823-38-4 / DENATURANT

Denatonium Saccharide is a synthetic compound renowned for its intensely bitter taste, functioning primarily as an aversive agent to deter accidental or intentional ingestion. It is detectable at extremely low concentrations, making it highly effective in preventing product consumption. For topical application, this ingredient does not offer any beneficial effects to the skin.

Summary

bittering agent

Science

Mechanism of Action

On the skin, Denatonium Saccharide operates as a cationic surfactant. This mechanism does not contribute to any known dermatological benefits and, conversely, carries the potential to induce irritation. Its primary function remains an aversive agent, recognized by a broad spectrum of human bitter taste receptors (e.g., TAS2R4, TAS2R8, TAS2R10), making products unpalatable if ingested.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Denatonium Saccharide provides no known beneficial skin effects, rendering it unsuitable for 'dusting' or making efficacy claims in skincare. Its only role is as an ingestion deterrent, not a skincare active ingredient.

The Formula

Formulation

Solubility
Oil
Optimal pH 5.5 – 7.5
0 7 14

Stability

This ingredient demonstrates high stability and inertness, typically not altering product properties due to its extremely low required concentrations. It remains stable across a moderate pH range.

Conflicts

  • strong oxidizing agents
  • Sodium Hypochlorite
  • Hydrogen Peroxide

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.1%
Sensitization risk Moderate

There is no specific CIR review for Denatonium Saccharide. However, a related compound, Denatonium Benzoate, is considered safe as a cosmetic denaturant. The EPA generally recognizes Denatonium Saccharide as safe for its bittering function. Clinical data indicates that concentrations exceeding 0.1% can produce irritating effects on intact skin, with significant irritation observed in the 1-10% range.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Moumoujus advises against the use of Denatonium Saccharide in precision skincare formulations due to its lack of beneficial skin effects and documented potential to cause irritation at concentrations above 0.1%.

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