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Moumoujus

DELTAMETHRIN.

Avoid CAS 52918-63-5 / NOT REPORTED

Deltamethrin is a synthetic pyrethroid primarily recognized for its potent insecticidal properties, functioning as a neurotoxin to control pests. While effective in treating parasitic infestations like scabies and lice at therapeutic doses, its interaction with human skin includes altering ion transport pathways and inducing sensory discomfort.

Summary

Science

Mechanism of Action

As a type II pyrethroid, Deltamethrin primarily impacts nerve cell membranes by delaying the closure of voltage-sensitive sodium ion channels. This action prolongs sodium permeability, generating repetitive nerve signals in sensory organs, nerves, and muscles. It also influences chloride channels and can increase the permeability of ions and water across human skin layers. Its interaction with nerve endings can depolarize presynaptic terminals, leading to heightened sensitivity to external stimuli and sensations such as paresthesia.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Pyrethroids, including deltamethrin, are utilized at recommended therapeutic concentrations for treating scabies and lice, with reported rare adverse effects.
  2. 02 Deltamethrin solutions have been shown to modulate ion transport mechanisms in human eyelid skin fragments, affecting sodium and chloride channels and enhancing ion and water permeability.

Transparency

Dusting Analysis

Not commonly dusted

Deltamethrin is primarily an insecticide and not an ingredient typically 'dusted' or found in cosmetic formulations for skin benefit. Its application is generally in pest control or specific medicinal treatments.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

Deltamethrin exhibits stability against hydrolysis within a pH range of 5 to 7. It is susceptible to degradation in alkaline conditions, with a half-life of 2.5 days at pH 9. Additionally, it undergoes gradual photoisomerization and photodegradation when exposed to sunlight, necessitating protective packaging.

Conflicts

  • Alkaline media
  • Exposure to sunlight

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not assessed Deltamethrin for cosmetic applications, nor has the SCCS. While the EPA classifies it as 'not likely to be carcinogenic to humans' and its technical grade has minimal dermal toxicity (Category III) and is non-irritating (Category IV), formulated products can induce slight to moderate skin irritation. High doses can lead to neurotoxic effects, manifesting as tingling, itching, burning, or numbness on the skin, typically resolving within 48 hours.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its primary role as a potent insecticide, lack of cosmetic benefit, and documented potential for neurotoxic sensory effects and irritation on human skin, Deltamethrin is unsuitable for skincare formulations.

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