Science
Mechanism of Action
Functioning as a synthetic prostaglandin analog, Dehydrolatanoprost interacts as a messenger with hair follicles by influencing G-protein coupled receptors. This action extends the anagen (growth) phase of the hair growth cycle, leading to the development of longer, thicker, and potentially darker eyelashes or eyebrows before they enter the natural shedding phase.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
This ingredient is a potent active intended for specific cosmetic effects (eyelash/eyebrow growth) and is not typically used in 'dusting' quantities for general skincare.
The Formula
Formulation
Safety
Safety Profile
The Scientific Committee on Consumer Safety (SCCS) of the European Union has expressed significant concerns regarding the safety of prostaglandin analogues, including Dehydrolatanoprost, in cosmetic products, particularly for application near the eye. The SCCS concluded in February 2022 that insufficient toxicological data were provided to determine safe use concentrations. Furthermore, a preliminary opinion from June 2025 indicated that these analogues could not be considered safe for cosmetic use due to potent pharmacological activity at low concentrations and a lack of data on potential adverse effects, including reproductive/developmental toxicity. Products making drug claims with this ingredient may be deemed unapproved new drugs by the FDA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to significant regulatory concerns regarding safety, a lack of comprehensive toxicological data to establish safe use concentrations, and potential pharmacological activity at low doses, this ingredient is not recommended for use in cosmetic formulations.
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