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Moumoujus

DEFATTED ISATIS TINCTORIA SEED EXTRACT.

Valuable / SKIN CONDITIONING

A refined botanical derivative from the Woad plant, concentrated through a defatting process to maximize bioactive alkaloids and glucosinolates. This precision ingredient serves as a multi-functional mediator, providing potent anti-inflammatory relief and senolytic activity to combat cellular aging.

Summary

Antioxidant Anti-inflammatory Skin-conditioning Senolytic (Anti-aging)

Science

Mechanism of Action

This extract functions through three primary pathways: first, it inhibits pro-inflammatory enzymes and cytokines, specifically reducing COX-2 activity and the expression of IL-6, IL-33, and TNF-α. Second, it acts as a senostatic agent, clearing senescent fibroblasts and suppressing the pro-aging Senescence-Associated Secretory Phenotype (SASP). Finally, its rich profile of flavonoids and indole alkaloids provides robust antioxidant defense against oxidative stress.

Research

Clinical Evidence

High confidence
Effective range 7–200%
Optimal

N/A

Key findings

  1. 01 In vitro assays demonstrate that 20 μg/ml of the extract can inhibit COX-2 enzyme activity by up to 95%.
  2. 02 Topical application at 100 μg/ml significantly reduced acute inflammatory responses and oedema by 51-67% in animal models.
  3. 03 Human keratinocyte studies show zero cytotoxicity up to 200 μg/mL, while effectively suppressing IL-1beta and IL-6 gene expression.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

While highly effective in low microgram concentrations for cellular signaling, botanical extracts like Isatis Tinctoria are often included at negligible levels (<0.1%) for marketing purposes. To achieve the documented senolytic and anti-inflammatory benefits, the extract should be present at higher active concentrations within the formulation.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Bioactive glucosinolates are thermosensitive; the ingredient must be processed at temperatures below 50 °C to maintain its structural integrity and biological efficiency.

Synergies

  • Niacinamide
  • Centella Asiatica
  • Hyaluronic Acid

Conflicts

  • High-heat processing phases

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

Listed in the EU CosIng Database. The defatting process removes erucic acid, enhancing the safety profile for topical cosmetic application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An outstanding multi-target botanical that bridges the gap between traditional herbalism and longevity science through its unique senolytic and cytokine-inhibiting properties.

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