Science
Mechanism of Action
As a synthetic prostaglandin analog, Dechloro Cyclopropylmethylcloprostenolamide operates by binding to specific prostaglandin receptors within the hair follicle. This interaction is believed to prolong the anagen (growth) phase of the hair cycle, resulting in increased hair shaft length, thickness, and pigmentation, particularly observed in eyelashes and eyebrows. There is currently no widely documented mechanism of action relating to general skin health, repair, or anti-aging effects beyond hair growth modulation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
While primarily known for its potent effects on hair growth, some sources inaccurately list this ingredient as a general antioxidant with no substantiated benefits, misrepresenting its actual pharmacological profile and potential applications in skincare.
The Formula
Formulation
Safety
Safety Profile
The Scientific Committee on Consumer Safety (SCCS) of the EU has concluded that prostaglandin analogues, including related compounds like Dechloro Dihydroxy Difluoro Ethylcloprostenolamide, cannot be considered safe for cosmetic use in eyelash and eyebrow growth products. This assessment stems from their potent pharmacological activity, even at low concentrations, and a lack of sufficient data to rule out serious adverse effects, notably reproductive/developmental toxicity. The Cosmetic Ingredient Review (CIR) has issued a 'Notice to Proceed' for related analogs, indicating significant data needs remain. This specific compound has not been individually reviewed by CIR.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its recognized efficacy in promoting hair growth, the significant safety concerns raised by regulatory bodies, including potential for systemic adverse effects and reproductive toxicity, strongly advise against its inclusion in cosmetic formulations.
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References
Sources