Science
Mechanism of Action
This ingredient functions as a prostaglandin analogue, activating specific prostanoid receptors within hair follicles. This interaction is theorized to stimulate resting hair follicles (telogen phase), initiating their transition into the active growth (anagen) phase, thereby promoting hair proliferation, mimicking effects of natural prostaglandins such as PGE2 and PGF2a.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Conflicts
- Not recommended for formulation in cosmetic products due to its potent pharmacological activity and the significant safety concerns articulated by regulatory bodies such as the SCCS.
Safety
Safety Profile
The Scientific Committee on Consumer Safety (SCCS) has definitively concluded that Dechloro Cyclopropylcloprostenolamide (also known as DDDE) cannot be considered safe for use in cosmetic products, even at low concentrations, particularly those marketed for eyelash and eyebrow growth. This is attributed to its potent pharmacological activity and a lack of adequate data to rule out potential adverse effects, including reproductive and developmental toxicity. The Cosmetic Ingredient Review (CIR) has also noted insufficient data for related prostaglandin analogues. Products containing such analogues may be classified as drugs by the FDA if their labeling implies a biological effect (e.g., lash growth), distinguishing them from cosmetic regulation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its potent pharmacological activity and significant safety concerns, including potential reproductive toxicity, regulatory bodies strongly advise against the use of Dechloro Cyclopropylcloprostenolamide in cosmetic formulations.
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References
Sources