Science
Mechanism of Action
SH-Decapeptide-5 SP acts as a skin conditioning and protecting agent by mimicking a portion of the human eosinophil cationic protein. This synthetic, single-chain peptide, composed of 10 specific amino acids including arginine, asparagine, and lysine, contributes to dermal benefits through its protective and conditioning attributes.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptides like Decapeptide-5 achieve optimal stability and dissolution within a near-neutral pH range of 6-8. They are susceptible to acid-catalyzed hydrolysis at pH 1-3 and base-catalyzed epimerization above pH 7. Hydrolysis can also occur at the N-terminal side of a serine residue at pH 5-6. For best stability, sterile, oxygen-free water or buffer (e.g., Tris or phosphate at pH 7) is recommended for solutions, with sonication potentially aiding dissolution and minimizing aggregation.
Conflicts
- Extreme pH values (acidic pH < 3, alkaline pH > 7)
- Topical corticosteroids (in medicinal contexts for vitiligo)
- Calcineurin inhibitors (in medicinal contexts for vitiligo)
- Broken, irritated, or infected skin (in medicinal contexts for vitiligo)
Safety
Safety Profile
The specific cosmetic ingredient SH-DECAPEPTIDE-5 SP has not undergone review by the CIR. However, other 'decapeptides' in medicinal vitiligo treatments (e.g., 0.1% solutions) are considered safe when prescribed, though some users may experience mild side effects like skin irritation, dryness, or a burning sensation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Decapeptide-5 is a synthetic peptide known for its skin conditioning and protecting properties, though comprehensive cosmetic clinical efficacy data and CIR review are currently unavailable.
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