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Moumoujus

DATURA STRAMONIUM LEAF EXTRACT.

Avoid CAS 84696-08-2 / SKIN CONDITIONING

Datura Stramonium Leaf Extract is an ingredient traditionally associated with antioxidant and anti-inflammatory properties, attributed to its diverse phytochemical composition. Despite some in-vitro efficacy, its use in precision skincare is highly problematic due to severe inherent toxicity.

Summary

Antioxidant Anti-inflammatory Skin Conditioning

Science

Mechanism of Action

This extract demonstrates antioxidant activity primarily through free radical scavenging, effectively inhibiting nitric oxide and potently neutralizing superoxide radicals. Its anti-inflammatory actions are believed to involve limiting the production of key inflammatory mediators and pro-inflammatory cytokines, alongside suppressing prostaglandin synthesis via cyclooxygenase (COX1 and COX2) inhibition. These effects are linked to phytochemicals such as phenols, tannins, saponins, flavonoids, and alkaloids.

Research

Clinical Evidence

Low confidence
Effective range 0.01–0.01%
Optimal

N/A

Key findings

  1. 01 An in-vitro study at 0.01% demonstrated significant free radical scavenging against nitric oxide, with ethanol extract showing 63.74% inhibition and ethyl acetate extract showing 52.02% inhibition.
  2. 02 The same in-vitro study at 0.01% revealed potent superoxide radical scavenging activity, achieving 91.41% inhibition with ethanol extract and 147.89% with ethyl acetate extract.

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.5%

While specific dusting thresholds for leaf extract are not established, seed extracts at concentrations exceeding 0.5% have been shown to induce adverse physiological modifications. This highlights the severe toxicity risk and lack of a safe cosmetic use concentration.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Datura Stramonium is highly toxic due to the presence of potent tropane alkaloids (atropine, scopolamine, hyoscyamine) throughout the plant. Ingestion or high doses can lead to severe central nervous system effects, including hallucinations, disorientation, and memory loss, alongside cardiovascular and respiratory complications, potentially proving fatal. Topical application carries a high likelihood of irritation, inflammation, and dryness. Due to its potent anticholinergic effects, it is contraindicated for individuals with conditions such as glaucoma, pyloric stenosis, paralytic ileus, tachycardia arrhythmias, enlarged prostate, or acute pulmonary edema.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite observed in-vitro antioxidant and anti-inflammatory activities, Datura Stramonium Leaf Extract is an ingredient to strictly avoid in skincare formulations due to its severe toxicity, high irritancy potential, and absence of established safety for topical cosmetic application.

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