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D-TRIMETHYL-3-CYCLOPENTENE-1-ACETALDEHYDE.

Questionable CAS 4501-58-0 / PERFUMING

D-Trimethyl-3-cyclopentene-1-acetaldehyde, an aldehyde compound, is predominantly utilized as a fragrance component in cosmetic formulations. While exhibiting various in vitro biological activities, its application for direct skincare benefits at defined concentrations remains unestablished. Notably, it is identified as a moderate skin sensitizer.

Fragrance

Science

As an aldehyde, D-Trimethyl-3-cyclopentene-1-acetaldehyde has demonstrated several biological activities in research, including antibacterial, antiviral, antifungal, anti-inflammatory, and antioxidant effects, along with cytotoxicity toward certain cancer cell lines. However, these reported mechanisms are general and lack specific elucidation for direct cosmetic efficacy on skin at regulated concentrations. Its primary role in formulations is attributed to its aromatic properties.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As an aldehyde, this compound is susceptible to nucleophilic addition, reduction, and condensation reactions, necessitating careful consideration during formulation to ensure stability.

Conflicts

  • strong nucleophiles
  • reducing agents

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

RIFM's comprehensive safety assessment indicates no concern for genotoxicity, phototoxicity, or photoallergenicity. However, it is classified as a moderate skin sensitizer with a No Expected Sensitization Induction Level (NESIL) of 500 µg/cm². This NESIL serves as the basis for maximum acceptable concentrations in finished products, which vary by specific product category.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Questionable

Primarily serving as a fragrance, this ingredient presents a moderate sensitization risk, and its potential biological activities are not established for direct skincare benefits at relevant concentrations.


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