Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

D-PULEGONE.

Avoid CAS 89-82-7 / PERFUMING

D-Pulegone is a naturally occurring monoterpene reported to possess anti-inflammatory, antioxidant, and antibiotic properties, primarily valued for its aromatic qualities. However, its application in skincare is severely restricted due to significant toxicity concerns, necessitating stringent concentration limits.

Summary

Anti-inflammatory Antioxidant Antibiotic Perfuming

Science

Mechanism of Action

In murine models, D-Pulegone has demonstrated the ability to inhibit inflammatory pathways by suppressing the NLRP3 inflammasome and reducing specific cytokine production. It also exhibits general antioxidant and antibiotic effects. Crucially, at elevated concentrations, its metabolites can deactivate cytochrome P450 enzymes, leading to hepatic toxicity, characterized by vascular dilation and cellular necrosis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
1%

The Cosmetic Ingredient Review (CIR) Expert Panel strictly limits D-Pulegone to 1% in cosmetic formulations due to substantial toxicity risks. This includes its classification as a Group 2B carcinogen (possibly carcinogenic to humans) and a chemical known to cause cancer under California's Prop 65. Exceeding this concentration presents unacceptable safety risks.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Reported to be stable under recommended storage conditions for the (R)-(+)-Pulegone enantiomer.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Moderate

The FDA does not authorize D-Pulegone as a synthetic flavoring substance. It is listed by the California Safe Cosmetics Program as a Group 2B carcinogen (possibly carcinogenic to humans) and a chemical known to cause cancer under Prop 65. The CIR Expert Panel mandates that its concentration in cosmetic formulations must not exceed 1% due to well-documented toxicity concerns.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a potential carcinogen under Prop 65, lack of FDA authorization, and strict 1% concentration limit due to toxicity, D-Pulegone poses significant safety concerns that far outweigh its documented anti-inflammatory and antioxidant benefits observed in non-human studies, making it unsuitable for precision skincare formulations.

Related

Similar Ingredients

Finding similar ingredients…